PubMed

Adico MDW, Zouré AA, Sombié HK, Kiendrebeogo TI, Dabré S, Amegnona LJ, Bakyono BS, Traoré L, Ouedraogo TC, Ouedraogo RA, Zohoncon TM, Yonli AT, Bayala B, Bambara HA, Djigma FW, Simpore J.Mol Genet Genomic Med. 2023 Apr;11(4):e2134. doi: 10.1002/mgg3.2134. Epub 2023 Jan 3.PMID: 36594475

Traoré ADD, Ky BD, Traoré L, Zohoncon TM, Zouré AA, Yonli AT, Sombié HK, Sorgho PA, Elvira Bazié BVJT, Tovo SFA, Kadanga E, Bakyono BS, Traore K, Ouédraogo TC, Djigma FW, Simpore J.

Abstract

Rubiaceae family is a large family of 630 genera and about 13000 species found worldwide, especially in tropical and warm regions. These plants are not only ornamental but they are also used in African folk medicine to treat several diseases. Based on online published data and library bibliographic research, we herein reported accumulated information related to their traditional usages in sub-Saharan traditional medicine, their chemical composition and the screened pharmacological activities. Indeed, more than 60 species are used for more than 70 medicinal indications including malaria, hepatitis, eczema, oedema, cough, hypertension, diabetes and sexual weakness. Through biological screening following leads supplied with traditional healers, many of these plants exhibited antimalarial, antimicrobial, antihypertension, antidiabetic, antioxidant and anti-inflammatory activities. Bioactive compounds including indole alkaloids, terpenoids and anthraquinones have been isolated from these bioguided fractionation studies. It is evidence that great attention has been paid to species such as Nauclea latifolia, Morinda lucida, Mitragyna inermis and Crossopteryx febrifuga; however, several compounds should be waiting to be discovered since none of these plants has been systematically investigated for its biochemical composition. According the current global health context with the recrudescence of HIV, much effort should be oriented towards this virus when screening Rubiaceae.

Zongo SV, Djigma FW, Yonli AT, Sorgho PA, Nagalo BM, Traore L, Somda D, Amegnona LJ, Languie E, Some CCB, Sia LMJ, Sourabie IB, Sombie RA, Serme AK, Obiri-Yeboah D, Simpore J. Mol Biol Rep. 2023 Apr 26. doi: 10.1007/s11033-023-08353-0. Online ahead of print. PMID: 37101005